NovaBioX® H-HPC
(Premium Cellulose Ether for Advanced Coatings)
Chemical Name: Hydroxypropyl cellulose
CAS No.: 9004-64-2
MF: (C3H7O)~n~
Hydroxypropyl cellulose is a water-soluble, non-ionic cellulose ether used extensively as a binder, film former, and thickening agent in pharmaceuticals, food, and cosmetics.
According to Chinese Pharmacopoeia 2020 Edition (Part IV).
Registration No.: F20180000537
Item | Specification |
Hydroxypropoxy content,Wt% | 53.4-80.5 |
Loss on drying,Wt% | ≤5.0 |
pH | 5.0-8.0 |
Residue on ignition,Wt% | ≤0.8 |
Arsenic, ppm | ＜2 |
Heavy metals, ppm | ≤10 |
Chlorides,Wt% | ≤0.15 |
Sulfur dioxide,Wt% | ≤0.6 |
Toluene,Wt% | ≤0.089 |
Isopropanol,Wt% | ≤0.5 |
Viscosity Specifications：
Grade | Concentration, % | Temperature, °C | Viscosity, mPa·s |
RT-G | 2 | 25 ± 0.2 | 150–400 |
RT-J | 5 | 25 ± 0.2 | 150–400 |
RT-L | 5 | 25 ± 0.2 | 75–150 |
RT-E | 10 | 25 ± 0.2 | 300–700 |
RT-M | 2 | 25 ± 0.2 | 4000–6500 |
RT-H | 2 | 25 ± 0.2 | 20000–50000 |
RT-LM | 2 | 25 ± 0.2 | 1000–3000 |
As a binder: In the pharmaceutical field, this product is mainly used as a binder, e.g., for tablets, granules, and pellet binders. The typical dosage is 1–5% of the drug weight. Choosing RT-L or RT-J type can increase tablet stability and hardness, with dissolution time superior to tablets using other binders.
As a film coating material for tablets: H-HPC has excellent film-forming properties, producing tough and elastic films. It can be used with plasticizers. Its low equilibrium moisture content allows further improvement in film stability when mixed with other excipients. RT-L type is generally selected.
As a thickener for coatings: Additive for coatings and stabilizer for emulsions. RT-M type is generally selected.
As a matrix material for sustained-release tablets: Sustained-release pellets and bilayer sustained-release tablets. RT-M type is generally selected.
As a gelling agent for drug combinations and as an ointment base: RT-M type is generally selected.
Due to its excellent film-forming properties, H-HPC can be dissolved in organic solvents to produce films with good tensile strength, serving as a carrier for local therapeutic drugs in the human body.
Dissolution in water:
Slowly add H-HPC into vigorously stirred water until completely dissolved. Rapid addition of the entire amount will make dissolution difficult.
Heat 20–30% of the required water to above 60 °C, slowly add H-HPC with thorough stirring. After all H-HPC has been added, add the remaining 70–80% of water to achieve complete dissolution.
Dissolution in organic solvents:
Slowly add H-HPC into the organic solvent with thorough stirring. Adding all at once makes dissolution very difficult.
Commonly used organic solvents:
Glacial acetic acid, acetone; water (9:1), benzene; methanol (1:1), chloroform, cyclohexanone, ethanol, formic acid (88%), glycerol; water (3:7), 95% isopropanol, methanol, dichloromethane; methanol (9:1), ethylene glycol,etc.
储存于阴凉、干燥、通风良好的库房中。避免受光直射，远离火源与热源。
在推荐存储条件下保质期为12个月。
